Signal transduction pathways used by NLR-type innate immune receptors

被引：41

作者：

Kufer, Thomas A. ^{[1
]}

机构：

[1] Univ Cologne, Inst Med Microbiol, Mol Innate Immunobiol Grp, D-50931 Cologne, Germany

来源：

MOLECULAR BIOSYSTEMS | 2008年 / 4卷 / 05期

关键词：

D O I：

10.1039/b718948f

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Proteins from the nucleotide-binding domain, LRR containing (NLR) family are involved in sensing bacterial invasion and danger signals in mammalian cells. Activation of these molecules leads to inflammatory responses which help clearance of invading pathogens. Recent data now shed light on the signal transduction pathways used by NLR proteins. This review summarizes advances in our understanding of signalling through NLRs with special emphasis on the Nod1 and Nod2 pathways.

引用

页码：380 / 386

页数：7

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