In vitro antitumor and antiviral activities of new benzothiazole and 1,3,4-oxadiazole-2-thione derivatives

被引：166

作者：

Akhtar, Tashfeen ^{[1
]}

Hameed, Shahid ^{[1
]}

Al-Masoudi, Najim A. ^{[2
]}

Loddo, Roberta ^{[3
]}

La Colla, Paolo ^{[3
]}

机构：

[1] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan

[2] Fachbereich Chem Univ, D-78457 Constance, Germany

[3] Univ Cagliari, Dept Biomed Sci & Technol, I-09042 Monserrato, CA, Italy

来源：

ACTA PHARMACEUTICA | 2008年 / 58卷 / 02期

关键词：

1,3,4-oxathiazoles; substituted benzothiazoles; antitumor activity; antiviral activity;

D O I：

10.2478/v10007-008-0007-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A series of new benzothiazole derivatives 6a-h have been synthesized, in five steps, from substituted phenols via the 1,3,4-oxadiazole-2-thiones 5a-h. The in vitro antitumor activity of the compounds obtained was investigated and the benzothiazol derivatives 6d and 6e showed strong effects on leukaemia cell lines CCRF-CEM (CC50 = 12 +/- 2 mu mol L-1, 8 +/- 1 mu mol L-1, respectively). These compounds are leading candidates for further development. The title compounds were tested against representatives of several virus families containing single stranded RNA genomes, either positive-sense (ssRNA+), or negative- sense (RNA-), and against double-stranded RNA genomes (dsRNA), as well as some Flaviviridae viruses.

引用

页码：135 / 149

页数：15

共 21 条

[1] 2-(3,4-Dichlorophenoxy)propionic acid [J].