Adhesion molecules in inflammatory bowel disease: Therapeutic implications for gut inflammation

被引：95

作者：

Danese, S ^{[1
]}

Semeraro, S ^{[1
]}

Marini, M ^{[1
]}

Roberto, I ^{[1
]}

Armuzzi, A ^{[1
]}

Papa, A ^{[1
]}

Gasbarrini, A ^{[1
]}

机构：

[1] Catholic Univ, Sch Med, Dept Internal Med, I-00168 Rome, Italy

来源：

DIGESTIVE AND LIVER DISEASE | 2005年 / 37卷 / 11期

关键词：

adhesion molecules; endothelium; leukocyte;

D O I：

10.1016/j.dld.2005.03.013

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Mucosal endothelium has become one of the major areas of investigation in gut inflammation. It is now well recognised that it plays an active role in the pathogenesis of both forms of inflammatory bowel disease, Crohn's disease and ulcerative colitis, since endothelial cells regulate mucosal immune homeostasis, acting as "gatekeepers", controlling leukocyte accumulation in the interstitial compartment. This process is mediated by leukocyte-endothelial adhesion molecules. This paper reviews the major molecules that mediate leukocyte-endothelial interactions, and summarises the results of the most recent clinical trials targeting adhesion molecules in inflammatory bowel disease. (C) 2005 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

引用

页码：811 / 818

页数：8

共 75 条

[1] Tumor necrosis factor α antibody (infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis [J].

Baert, FJ ;

D'Haens, GR ;

Peeters, M ;

Hiele, MI ;

Schaible, TF ;

Shealy, D ;

Geboes, K ;

Rutgeerts, PJ .

GASTROENTEROLOGY, 1999, 116 (01) :22-28

[2] BINDING OF L-SELECTIN TO THE VASCULAR SIALOMUCIN CD34 [J].

BAUMHUETER, S ;

SINGER, MS ;

HENZEL, W ;

HEMMERICH, S ;

RENZ, M ;

ROSEN, SD ;

LASKY, LA .

SCIENCE, 1993, 262 (5132) :436-438

[3]

BELL RG, 1993, J IMMUNOL, V151, P4790

[4] The role of very late antigen-1 in immune-mediated inflammation [J].

Ben-Horin, S ;

Bank, I .

CLINICAL IMMUNOLOGY, 2004, 113 (02) :119-129

[5] ALPHA-4-BETA-7-INTEGRIN MEDIATES LYMPHOCYTE BINDING TO THE MUCOSAL VASCULAR ADDRESSIN MADCAM-1 [J].

BERLIN, C ;

BERG, EL ;

BRISKIN, MJ ;

ANDREW, DP ;

KILSHAW, PJ ;

HOLZMANN, B ;

WEISSMAN, IL ;

HAMANN, A ;

BUTCHER, EC .

CELL, 1993, 74 (01) :185-195

[6]

Bernstein CN, 1996, CLIN EXP IMMUNOL, V106, P160

[7] Enhanced leukocyte binding by intestinal microvascular endothelial cells in inflammatory bowel disease [J].

Binion, DG ;

West, GA ;

Ina, K ;

Ziats, NP ;

Emancipator, SN ;

Fiocchi, C .

GASTROENTEROLOGY, 1997, 112 (06) :1895-1907

[8] Acquired increase in leucocyte binding by intestinal microvascular endothelium in inflammatory bowel disease [J].

Binion, DG ;

West, GA ;

Volk, EE ;

Drazba, JA ;

Ziats, NP ;

Petras, RE ;

Fiocchi, C .

LANCET, 1998, 352 (9142) :1742-1746

[9]

BRISCOE DM, 1992, J IMMUNOL, V149, P2954

[10] A new role in hemostasis for the adhesion receptor P-selectin [J].

Cambien, B ;

Wagner, DD .

TRENDS IN MOLECULAR MEDICINE, 2004, 10 (04) :179-186

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