Executive Summary of the Stages of Reproductive Aging Workshop+10: Addressing the Unfinished Agenda of Staging Reproductive Aging

被引:401
作者
Harlow, Sioban D. [1 ]
Gass, Margery [2 ]
Hall, Janet E. [3 ]
Lobo, Roger [4 ]
Maki, Pauline [5 ]
Rebar, Robert W. [6 ]
Sherman, Sherry [7 ]
Sluss, Patrick M. [8 ]
de Villiers, Tobie J. [9 ]
机构
[1] Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA
[2] N Amer Menopause Soc, Mayfield Hts, OH USA
[3] Harvard Univ, Sch Med, Dept Med, Endocrine Soc, Boston, MA USA
[4] Columbia Univ, Dept Obstet & Gynecol, New York, NY USA
[5] Univ Illinois, Dept Psychiat & Psychol, Chicago, IL USA
[6] Amer Soc Reprod Med, Birmingham, AL USA
[7] NIA, Bethesda, MD 20892 USA
[8] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
[9] Int Menopause Soc, Cape Town, South Africa
基金
美国国家卫生研究院;
关键词
ANTI-MULLERIAN HORMONE; FOLLICLE-STIMULATING-HORMONE; POLYCYSTIC-OVARY-SYNDROME; EARLY MENOPAUSAL TRANSITION; REGULAR MENSTRUAL CYCLES; INHIBIN-B; WOMENS HEALTH; ANTIMULLERIAN HORMONE; LONGITUDINAL CHANGES; DEPRESSIVE SYMPTOMS;
D O I
10.1210/jc.2011-3362
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Objective: The aim of this article is to summarize the recommended updates to the 2001 Stages of Reproductive Aging Workshop (STRAW) criteria. The 2011 STRAW + 10 reviewed advances in understanding of the critical changes in hypothalamic-pituitary-ovarian function that occur before and after the final menstrual period. Methods: Scientists from five countries and multiple disciplines evaluated data from cohort studies of midlife women and in the context of chronic illness and endocrine disorders on change in menstrual, endocrine, and ovarian markers of reproductive aging including antimullerian hormone, inhibin-B, follicle-stimulating hormone, and antral follicle count. Modifications were adopted by consensus. Results: STRAW + 10 simplified bleeding criteria for the early and late menopausal transition, recommended modifications to criteria for the late reproductive stage (Stage -3) and the early postmenopause stage (Stage +1), provided information on the duration of the late transition (Stage-1) and early postmenopause (Stage + 1), and recommended application regardless of women's age, ethnicity, body size, or lifestyle characteristics. Conclusions: STRAW + 10 provides a more comprehensive basis for assessing reproductive aging in research and clinical contexts. Application of the STRAW + 10 staging system should improve comparability of studies of midlife women and facilitate clinical decision making. Nonetheless, important knowledge gaps persist, and seven research priorities are identified. (J Clin Endocrinol Metab 97: 1159-1168, 2012)
引用
收藏
页码:1159 / 1168
页数:10
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