Peptide-PNA conjugates: Targeted transport of antisense therapeutics into tumors

被引：34

作者：

Mier, W

Eritja, R

Mohammed, A

Haberkorn, U

Eisenhut, M

机构：

[1] Univ Klinikum Heidelberg, Radiol Klin, Abt Nukl Med, D-69120 Heidelberg, Germany

[2] CSIC, Cid, ES-08034 Barcelona, Spain

[3] Deutsch Krebsforschungszentrum, D-69120 Heidelberg, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 17期

关键词：

antisense agents; drug delivery; peptide nucleic acids; peptides; solid-phase synthesis;

D O I：

10.1002/anie.200219978

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tumor-specific accumulation of antisense therapeutics: The conjugation of a receptor-binding peptide allows for the first time the selective transport of oligonucleotide analogues into tumor tissue. By using the tert-butyloxycarbonyl (Boc) protecting group stratergy, hybrids of peptide nucleic acids and peptides are accessible that accumulate in tumor tissue at a tenfold higher concentration than the free peptide nucleic acid.

引用

页码：1968 / 1971

页数：4

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