Ion channels:: A first view of K+ channels in atomic glory

被引：12

作者：

Sansom, MSP ^{[1
]}

机构：

[1] Univ Oxford, Mol Biophys Lab, Oxford OX1 3QU, England

来源：

CURRENT BIOLOGY | 1998年 / 8卷 / 13期

关键词：

D O I：

10.1016/S0960-9822(98)70290-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Crystal structures have been solved foe the transbilayer pore domain of a bacterial K+ channel and the tetramerisation domain of a voltage-gated K+ channel. These provide our first real structural insights into possible mechanisms of ion selectivity and permeation for K+ channels. (C) Current Biology Ltd.

引用

页码：R450 / R452

页数：3

共 10 条

[1] How many membrane proteins are there? [J].

Boyd, D ;

Schierle, C ;

Beckwith, J .

PROTEIN SCIENCE, 1998, 7 (01) :201-205

[2] pH-dependent gating in the Streptomyces lividans K+ channel [J].

Cuello, LG ;

Romero, JG ;

Cortes, DM ;

Perozo, E .

BIOCHEMISTRY, 1998, 37 (10) :3229-3236

[3] The structure of the potassium channel:: Molecular basis of K+ conduction and selectivity [J].

Doyle, DA ;

Cabral, JM ;

Pfuetzner, RA ;

Kuo, AL ;

Gulbis, JM ;

Cohen, SL ;

Chait, BT ;

MacKinnon, R .

SCIENCE, 1998, 280 (5360) :69-77

[4] Structural model of the outer vestibule and selectivity filter of the Shaker voltage-gated K+ channel [J].

Durell, SR ;

Guy, HR .

NEUROPHARMACOLOGY, 1996, 35 (07) :761-773

[5]

Hille B., 1992, IONIC CHANNELS EXCIT

[6] The pore-lining region of shaker voltage-gated potassium channels: Comparison of beta-barrel and alpha-helix bundle models [J].

Kerr, ID ;

Sansom, MSP .

BIOPHYSICAL JOURNAL, 1997, 73 (02) :581-602

[7] Crystal structure of the tetramerization domain of the Shaker potassium channel [J].

Kreusch, A ;

Pfaffinger, PJ ;

Stevens, CF ;

Choe, S .

NATURE, 1998, 392 (6679) :945-948

[8] Structural conservation in prokaryotic and eukaryotic potassium channels [J].

MacKinnon, R ;

Cohen, SL ;

Kuo, AL ;

Lee, A ;

Chait, BT .

SCIENCE, 1998, 280 (5360) :106-109

[9] MOLECULAR-DYNAMICS SIMULATIONS OF THE GRAMICIDIN CHANNEL [J].

ROUX, B ;

KARPLUS, M .

ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 1994, 23 :731-761

[10] A PROKARYOTIC POTASSIUM-ION CHANNEL WITH 2 PREDICTED TRANSMEMBRANE SEGMENTS FROM STREPTOMYCES-LIVIDANS [J].

SCHREMPF, H ;

SCHMIDT, O ;

KUMMERLEN, R ;

HINNAH, S ;

MULLER, D ;

BETZLER, M ;

STEINKAMP, T ;

WAGNER, R .

EMBO JOURNAL, 1995, 14 (21) :5170-5178

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