Specific IgE to recombinant vegetal panallergen (rBet v 2) and fruit allergy in pollinic patients

The presence of IgE antibodies to the allergens rBet vl and rBet v 2 was investigated in patients with known sensitization to ryegrass (Lolium perenne) and/or olive (Olea europaea) pollen, by comparing a group of 10 patients who had allergic symptoms after ingestion of fruits (A) with a group of 17 patients who had only seasonal respiratory symptoms (B). There was no significant difference between the two groups for total IgE. All patients showed specific IgE to both L. perenne and O. europaea. No specific IgE binding to rBet v 1 was detected in any patient. The incidence of the presence of IgE antibodies to rBet v 2 was 90% in the group with fruit allergy (A) and 35% in group B. We found a significant association between presence of IgE antibodies to rBet v 2 and fruit allergy (P=0.007). Specific IgE values to O. europaea pollen were higher in the fruit-allergy group than the group without fruit allergy (P=0.032). In conclusion, pollen-allergic patients with specific IgE to birch pollen profilin show a significantly elevated frequency of fruit allergy.