The Gln27Glu Polymorphism in β2-Adrenergic receptor gene is linked to hypertriglyceridemia, hyperinsulinemia and hyperleptinemia in Saudis

Background: beta 2-adrenoceptor (beta 2AR) gene polymorphism glutamine 27 glutamic acid (Gln27Glu) and Arg16Gly were reported to have an association with obesity and obesity related disorders in some population. We evaluated Gln27Glu polymorphism in the beta 2AR gene in obese Saudi populations to investigate the association of beta 2AR gene with obesity and other related metabolic parameters. Design: We studied possible association of Gln27Glu in beta 2AR gene with body mass index (BMI), anthropometric measurements and other metabolic parameters. The beta 2AR gene polymorphism (Gln27Glu) was identified by sequencing PCR products representing locus of interest. Based on BMI, the subjects were divided into three groups, normal weight, overweight and obese. The genotype and allele frequency were calculated separately for each group. Results: The allelic frequency of Glu27 did not differ amongst the three groups, though the Glu27 homozygote (Glu/Glu) were more in obese subjects and had higher concentration of triglyceride, leptin and insulin compared to in the Gln27 heterozygotes and Gln/Gln homozygotes. Conclusions: In this study we were able to provide evidence on the influence of Gln27Glu genetic variant of beta 2AR gene on lipid phenotypes, insulin and leptin levels in the Saudi populations.