Effect of high-fat diet on KKAy and ob/ob mouse liver and adipose tissue corticosterone and 11-dehydrocorticosterone concentrations

被引：33

作者：

Alberts, P ^{[1
]}

Rönquist-Nii, Y ^{[1
]}

Larsson, C ^{[1
]}

Klingström, G ^{[1
]}

Engblom, L ^{[1
]}

Edling, N ^{[1
]}

Lidell, V ^{[1
]}

Berg, I ^{[1
]}

Edlund, PO ^{[1
]}

Ashkzari, M ^{[1
]}

Sahaf, N ^{[1
]}

Norling, S ^{[1
]}

Berggren, V ^{[1
]}

Bergdahl, K ^{[1
]}

Forsgren, M ^{[1
]}

Abrahmsén, L ^{[1
]}

机构：

[1] Biovitrum, Dept Biol, SE-11276 Stockholm, Sweden

来源：

HORMONE AND METABOLIC RESEARCH | 2005年 / 37卷 / 07期

关键词：

11-dehydrocorticosterone; corticosterone; diabetes; glucocorticoids; 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1); metabolic syndrome; obesity;

D O I：

10.1055/s-2005-870228

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The present study was performed to compare glucocorticoid levels in obese KKA(y) and ob/ob mice with those in normal C5713L/6J mice, and the effect of high-fat diet on glucocorticoids in KKA(y) and ob/ob mice. Liver, mesenteric and epididymal adipose tissue corticosterone and 11-dehydrocorticosterone concentrations as well as circulating corticosterone concentrations were measured. The KKA(y) and ob/ob mice displayed elevated serum corticosterone levels compared to normal mice, 2.0 to 2.8-fold in KKA(y), and 11 to 16-fold in ob/ob mice. Liver corticosterone levels were 3.0 to 5.1 and 6.2 to 8.1-fold, and 11-dehydrocorticosterone levels were 3.4 to 3.6 and 6.7 to 8.2-fold higher in KKA(y) and ob/ob mice compared to normal mice. Mesenteric adipose tissue corticosterone levels were 2.7 to 4.2-fold higher, and 11-dehydrocorticosterone levels were 2 to 4-fold higher in ob/ob than in KKA(y) mice. Epididymal adipose tissue corticosterone levels were 3.0 to 6.2-fold higher, and 11-dehydrocorticosterone levels were 1.8 to 2.0-fold higher in ob/ob than in KKA(y) mice. Circulating, hepatic, and mesenteric and epididymal adipose tissue glucocorticoid concentrations were low in the normal C5713L/6J mouse, high in the ob/ob mouse, and intermediate in the KKA(y) mouse. 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) mRNA levels were doubled in ob/ob compared to KKA(y) mice in all three tissues. Glucocorticoid concentrations correlated with 11 beta-HSD1 mRNA levels. High-fat diet had no effect on the tissue glucocorticoid concentrations.

引用

页码：402 / 407

页数：6

共 29 条

[1] Selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains [J].