Inhibition of angiogenesis by small-molecule antagonists of protease-activated receptor-1

被引：38

作者：

Tsopanoglou, Nikos E. ^{[1
]}

Maragoudakis, Michaeg E. ^{[1
]}

机构：

[1] Univ Patras, Sch Med, Dept Pharmacol, Patras 26500, Greece

来源：

SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2007年 / 33卷 / 07期

关键词：

thrombin; PAR-1; antagonists; angiogenesis; tumor growth; cardiovascular diseases;

D O I：

10.1055/s-2007-991535

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Angiogenesis, the growth of new blood vessels from preexisting ones, is a necessary component of embryogenesis, wound healing, and the proliferative phase of the female reproductive cycle. Angiogenesis also plays a critical role in important pathologic processes such as cancer and cardiovascular complications. In addition, clinical, laboratory, and pharmacologic evidence has shown a link between angiogenesis, coagulation, hemostasis, and thrombosis in the settings of these pathologies. Recent studies in our laboratory revealed that thrombin has a significant stimulatory effect on angiogenesis. This effect of thrombin is independent of fibrin formation and can be attributed mainly to the activation of protease-activated receptor-1 (PAR-1). PAR-1 is widely expressed in vascular cells and is involved in cardiovascular complications such as atherosclerosis, restenosis, and neointimal formation. It is also expressed in many cancer cells contributing to induction of tumor growth and metastasis. In this review, we will summarize our present-day understanding of the role of thrombin and PAR-1 in angiogenesis and the potential therapeutic utility of targeting PAR-1 in angiogenesis-related disease, such as atherosclerosis, restenosis, and cancer.

引用

页码：680 / 687

页数：8

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