Reducing the incidence and severity of pericardial adhesions with a sprayable polymeric matrix

被引:45
作者
Konertz, WF
Kostelka, M
Mohr, FW
Hetzer, R
Hübler, M
Ritter, J
Liu, J
Koch, C
Block, JE
机构
[1] Univ Hosp Heart Ctr, Leipzig, Germany
[2] Univ Hosp Cardiovasc Surg, Charite, Berlin, Germany
[3] German Heart Inst, Berlin, Germany
关键词
D O I
10.1016/S0003-4975(03)00733-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose. This study was undertaken to evaluate the antiadhesive properties of a polymeric agent in infants undergoing staged surgical correction of congenital heart abnormalities. Description. Sixteen infants having staged surgical repair were treated with a polymeric matrix at the completion of the initial surgery. There were 5 untreated controls. The tenacity and extent of adhesions at five separate regions of the heart were evaluated at the follow-up surgery. Evaluation. For all sites combined, there was a threefold difference in median tenacity scores in favor of the experimental treatment (1.0 vs 3.0, p < 0.01). Significant differences were achieved separately at the right ventricle and the anterior surface of the great vessels (p = 0.02 for both comparisons). Analysis of adhesion scores reflecting the extent of adhesions similarly favored the experimental treatment for all sites (80 vs; 270, p < 0.01), with significant differences persisting at the right atrium (p < 0.01) and the anterior surface of the great vessels (p = 0.04). There were no treatment-related adverse events. Conclusions. Use of this polymeric agent at the completion of open cardiac surgery may prevent the occurrence or reduce the severity of pericardial adhesions.
引用
收藏
页码:1270 / 1274
页数:5
相关论文
共 11 条
[1]  
BAILEY LL, 1984, J THORAC CARDIOV SUR, V87, P539
[2]  
CLIFF WJ, 1973, J THORAC CARDIOV SUR, V65, P744
[3]   CATASTROPHIC HEMORRHAGE DURING REDO STERNOTOMY [J].
DOBELL, ARC ;
JAIN, AK .
ANNALS OF THORACIC SURGERY, 1984, 37 (04) :273-278
[4]   A polymeric sealant inhibits anastomotic suture hole bleeding more rapidly than gelfoam/thrombin - Results of a randomized controlled trial [J].
Glickman, M ;
Gheissari, A ;
Money, S ;
Martin, J ;
Ballard, JL .
ARCHIVES OF SURGERY, 2002, 137 (03) :326-331
[5]  
Hendrikx M, 2001, HEART SURG FORUM, V4, P204
[6]  
Hill A, 2001, J BIOMED MATER RES, V58, P308, DOI 10.1002/1097-4636(2001)58:3<308::AID-JBM1022>3.3.CO
[7]  
2-G
[8]   Pericardial trauma and adhesions in relation to reoperative cardiac surgery [J].
Nkere, UU ;
Whawell, SA ;
Sarraf, CE ;
Schofield, JB ;
Thompson, JN ;
Taylor, KM .
THORACIC AND CARDIOVASCULAR SURGEON, 1995, 43 (06) :338-346
[9]  
Shapira N, 1990, Am J Cardiovasc Pathol, V3, P87
[10]   CORONARY-ARTERY BYPASS OCCLUSION SECONDARY TO POSTCARDIOTOMY SYNDROME [J].
URSCHEL, HC ;
RAZZUK, MA ;
GARDNER, M .
ANNALS OF THORACIC SURGERY, 1976, 22 (06) :528-531