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5α-reductase inhibitory tannin-related compounds isolated from Shorea laeviforia

被引：18
作者：
Hirano, Y
Kondo, R
Sakai, K
机构：
[1] Interior Design Res Inst, Fukuoka Ind Technol Ctr, Fukuoka 8310031, Japan
[2] Kyushu Univ, Fac Agr, Dept Forest & Forest Prod Sci, Fukuoka 8128581, Japan
来源：
JOURNAL OF WOOD SCIENCE | 2003年 / 49卷 / 04期
关键词：
Shorea laeviforia; tannin-related compounds; valoneic acid dilactone; gallagyldilactone; 5 alpha-reductase inhibitor;
D O I：
10.1007/s10086-002-0481-y
中图分类号：
S7 [林业];
学科分类号：
0829 ; 0907 ;
摘要：
Five tannin-related compounds - gallic acid, flavogallonic acid dilactone, valoneic acid dilactone, gallagyldilactone, ellagic acid - were isolated from the heartwood of Shorea laevifbria, and the inhibitory activity of each against rat liver 5alpha-reductase was evaluated. Valoneic acid dilactone and gallagyldilactone exhibited positive inhibitory activity, but gallic acid and ellagic acid did not. Flavogallonic acid dilactone stimulated 5alpha-reductase activity, even though this compound is structurally similar to valoneic acid dilactone. The kinetic study of valoneic acid dilactone and gallagyldilactone indicated that the inhibitory behavior of 5alpha-reductase were not competitive against the substrate (testosterone) and were partially competitive against the cofactor (NADPH). Additionally, double inhibition analysis of valoneic acid dilactone and NADP(+) showed synergetic inhibition. These results suggested that neither valoneic acid dilactone nor gallagyldilactone can affect the binding of testosterone but that either compound could interact with an enzyme-NADP(+) complex to inhibit 5alpha-reductase.
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页码：339 / 343
页数：5
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