Determination of solubility of polymorphs using differential scanning calorimetry

被引：110

作者：

Park, K ^{[1
]}

Evans, JMB ^{[1
]}

Myerson, AS ^{[1
]}

机构：

[1] IIT, Dept Chem Engn, Chicago, IL 60616 USA

来源：

CRYSTAL GROWTH & DESIGN | 2003年 / 3卷 / 06期

关键词：

D O I：

10.1021/cg0340502

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this paper, we present a technique for determining the solubility of both stable and metastable polymorphs. The technique was developed during a study of the thermodynamic relationships, between the polymorphic forms of carbamazepine (forms I and 111), glycine (alpha and gamma forms), and mefenamic acid (forms I and II), using a Mettler Toledo 822(e) differential scanning calorimeter (DSC). The three systems under investigation were found to be enantiotropic with transition points at 78 degreesC (carbamazepine), 177 degreesC (glycine), and 86.6 degreesC (mefenamic acid). Solubility determination of the metastable polymorphic form of the systems was carried out by slow heating (0.08 K/min) of the sample, and using heat flow derivative curves, where the saturation point and hence the solubility at a known weight percentage are given by the peak of a heat flow curve.

引用

页码：991 / 995

页数：5

共 21 条

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