Role of glycoprotein la gene polymorphisms in determining platelet function in myocardial infarction patients undergoing percutaneous coronary intervention on dual antiplatelet treatment

被引：29

作者：

Giusti, Betti ^{[1
,2
]}

Gori, Anna Maria ^{[1
,2
]}

Marcucci, Rossella ^{[1
,2
]}

Sestini, Ilaria ^{[1
,2
]}

Saracini, Claudia ^{[1
,2
]}

Paniccia, Rita ^{[1
,2
]}

Poli, Serena ^{[1
,2
]}

Giglioli, Cristina ^{[1
,2
]}

Valente, Serafina ^{[1
,2
]}

Priscoa, Domenico ^{[1
,2
]}

Gensini, Gian Franco ^{[1
,2
,3
]}

Abbate, Rosanna ^{[1
,2
]}

机构：

[1] Univ Florence, Dept Med & Surg Crit Care, I-50134 Florence, Italy

[2] Univ Florence, DENOTHE, Ctr Res Transfer & High Educ, I-50134 Florence, Italy

[3] Fdn Don Carlo Gnocchi Onlus IRCCS, Ctr S Maria Ulivi, Florence, Italy

来源：

ATHEROSCLEROSIS | 2008年 / 196卷 / 01期

关键词：

glycoprotein la polymorphisms; residual platelet reactivity; aspirin resistance; antiplatelet treatment; percutaneous coronary intervention;

D O I：

10.1016/j.atherosclerosis.2006.11.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Response variability to antiplatelet treatment has been described and the widespread use of acetylsalicylic acid (ASA) and clopidogrel requires clarification of the residual platelet reactivity (RPR). Various glycoprotein la (GpIa) polymorphisms have been investigated, but their influence on platelet reactivity in myocardial infarction (MI) patients undergoing percutaneous coronary intervention (PCI) on dual antiplatelet treatment is not still elucidated. Aim of this study was to evaluate the effect of C807T, G873A and T837C polymorphisms of GpIa on modulating platelet function in MI patients on dual antiplatelet treatment undergoing PCI. We measured platelet function by both a point-of-care assay (PFA 100) and platelet-rich-plasma aggregation in 289 MI patients undergoing PCI and receiving dual antiplatelet treatment. Our data show that C807T/G873A polymorphisms, but not T837C, are associated with higher platelet reactivity. Carriers of the 807T/873A allele had significantly higher platelet aggregation values after arachidonic acid (AA) and collagen stimuli and, even if they did not reach the statistical significance, after 2 and 10 mu M ADP stimuli; 807T/873A allele carriers had also significantly shorter closure times on PFA 100/epinephrine membranes. At the multiple analyses, C807T/G873A polymorphisms resulted an independent risk factor for RPR defined by both AA induced platelet aggregation (OR = 3.0, 95%CI 1.17-7.89 p = 0.022) or by PFA 100/epinephrine (OR = 4.1, 95%CI 1.53-10.89, to = 0.005). In conclusion, this study shows the 807T/873A allele of the GpIa gene is an independent risk factor for the RPR on dual antiplatelet treatment, and extends, in a larger acute coronary syndrome population, the observation that the 807T/873A allele is associated with higher platelet reactivity. (C) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：341 / 348

页数：8

共 32 条

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