Nitric oxide and blood: a review

被引：46

作者：

Wallis, JP ^{[1
]}

机构：

[1] Freeman Rd Hosp, Dept Haematol, Newcastle Upon Tyne NE7 7DN, Tyne & Wear, England

来源：

TRANSFUSION MEDICINE | 2005年 / 15卷 / 01期

关键词：

nitric oxide; nitrosothiols; platelets; red cells; transfusion;

D O I：

10.1111/j.1365-3148.2005.00542.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nitric oxide (NO) was identified as a physiological mediator of vascular tone in 1987. NO produced by endothelial cells causes vasodilatation and also inhibits platelet aggregation and leucocyte adhesion. Red cells metabolize NO to nitrate but may possibly carry and release, or even produce, NO in hypoxic conditions. NO physiology may have important implications for transfusion medicine, ranging from adverse effects of haemoglobin substitutes to preservation of stored platelets and to detrimental effects of stored red cells.

引用

页码：1 / 11

页数：11

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