Breast cancer stem cells-research opportunities utilizing mathematical Modeling

被引：11

作者：

Ashkenazi, Rina

Jackson, Trachette L.

Dontu, Gabriela

Wicha, Max S.

机构：

[1] Univ Michigan, Dept Internal Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Math, Ann Arbor, MI 48109 USA

来源：

STEM CELL REVIEWS | 2007年 / 3卷 / 02期

关键词：

cancer stem cells; mathematical modeling; self-renewal; carcinogenesis;

D O I：

10.1007/s12015-007-0026-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

There is increasing evidence for the "cancer stem cell hypothesis" which holds that cancers originate in tissue stem cells or progenitor cells. As a result of this, cancers are driven by a cellular subcomponent that retains stem cell properties. Among these properties are self-renewal and multi-lineage differentiation. The biological processes which account for stem cell properties are currently being elucidated. Cancer stem cells maintain many of the same characteristics of their normal counterparts. The combination of biological research with mathematical modeling may provide for a greater understanding of the complex picture of breast cancer stem cells and assist cancer biologists and clinical oncologists in designing and testing novel therapeutic strategies.

引用

页码：176 / 182

页数：7

共 33 条

[1] Prospective identification of tumorigenic breast cancer cells [J].