Homocysteine, vitamin B6 and the risk of recurrent venous thromboembolism

被引：20

作者：

Eichinger, S ^{[1
]}

机构：

[1] Allgemeines Krankenhaus Wien, Div Hematol & Hemostasis, Dept Internal Med 1, A-1090 Vienna, Austria

来源：

PATHOPHYSIOLOGY OF HAEMOSTASIS AND THROMBOSIS | 2003年 / 33卷 / 5-6期

关键词：

homocysteine; venous thrombosis recurrence; vitamin B6;

D O I：

10.1159/000083825

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hyperhomocysteinemia (HHC) is an independent risk factor for cardiovascular disease, and even mildly to moderately elevated homocysteine levels have been associated with a heightened risk for a first and recurrent venous thromboembolism (VTE). Within the frame of a large prospective cohort study (Austrian Study on Recurrent Venous Thromboembolism), we assessed the impact of HHC on the risk of recurrence among 602 patients with a first unprovoked VTE. HHC was an independent risk factor of recurrence conferring a relative risk of 1.5 (95th% CI 1.0-2.4). HHC is caused either by genetic defects and/or by a deficiency of the vitamins (B12, B6 and folic acid) involved in the homocysteine metabolism. Low vitamin B6 levels are associated with an increased risk of a first venous thrombosis. We currently investigate whether or not low plasma levels of PLP are associated with a heightened risk for recurrent VTE. Copyright (C) 2004 S. Karger AG, Basel.

引用

页码：342 / 344

页数：3

共 12 条

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