A comparative study of five nitro musk compounds for genotoxicity in the SOS chromotest and Salmonella mutagenicity

被引：32

作者：

Emig, M ^{[1
]}

Reinhardt, A ^{[1
]}

MerschSundermann, V ^{[1
]}

机构：

[1] KLINIKUM MANNHEIM,INST MED MIKROBIOL & HYG,D-68135 MANNHEIM,GERMANY

来源：

TOXICOLOGY LETTERS | 1996年 / 85卷 / 03期

关键词：

nitro musk; mutagenicity; genotoxicity; SOS chromotest; Salmonella test;

D O I：

10.1016/0378-4274(96)03667-3

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Five nitro musk compounds widely used in cosmetics and detergents were examined for DNA-damaging and mutation-inducing properties. For this purpose two short-time assays were used, the SOS chromotest and the Salmonella/mammalian microsome test. Musk ambrette showed mutagenicity in Salmonella typhimurium TA 100 requiring metabolic activation by rat liver postmitochondrial supernatant (S9) but it lacked mutagenicity in the absence of S9 and genotoxicity in the SOS chromotest. Musk xylene, musk ketone, musk moskene and musk tibetene showed neither mutagenicity nor genotoxicity in the presence and absence of S9.

引用

页码：151 / 156

页数：6

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