Microbial transformation of taxoids: Selective deacetylation and hydroxylation of 2 alpha,5 alpha,10 beta,14 beta-tetra-acetoxy-4(20),11-taxadiene by the fungus Cunninghamella echinulata

被引：30

作者：

Hu, SH ^{[1
]}

Tian, XF ^{[1
]}

Zhu, WH ^{[1
]}

Fang, QC ^{[1
]}

机构：

[1] BEIJING UNION MED COLL,BEIJING 100050,PEOPLES R CHINA

来源：

TETRAHEDRON | 1996年 / 52卷 / 26期

关键词：

D O I：

10.1016/0040-4020(96)00426-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

The fungal genus Cunninghamella, in particular, Cunninghamella echinulata AS 3.1990 selectively transformed 2 alpha,5 alpha,10 beta,14 beta-tetra-acetoxy-4(20),11-taxadiene(1) to give 6 alpha,10 beta-dihydroxy- 2 alpha,5 alpha,14 beta-triacetoxy-4(20),11-taxadiene(2) in moderate yield (33%), along with 6 beta,10 beta-dihydroxy-2 alpha,5 alpha,14 beta-triacetoxy-4(20),11-taxadiene(3), 10 beta-hydroxy-2 alpha,5 alpha,14 beta-triacetoxy-taxadiene(4), 10 beta-hydroxy-4 beta,20-epoxy-2 alpha 5 alpha,14 beta-triacetoxy-tax-11-ene(5) as minor products. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：8739 / 8746

页数：8

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