Cannabinoid CB1 receptor upregulation in a rat model of chronic neuropathic pain

被引：86

作者：

Siegling, A ^{[1
]}

Hofmann, HA ^{[1
]}

Denzer, D ^{[1
]}

Mauler, F ^{[1
]}

De Vry, J ^{[1
]}

机构：

[1] Bayer AG, CNS Res, D-42096 Wuppertal, Germany

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2001年 / 415卷 / 01期

关键词：

analgesia; cannabinoid CB1 receptor; tibial nerve injury;

D O I：

10.1016/S0014-2999(01)00798-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Although cannabinoids are known to be more effective analgesics against chronic rather than acute pain, the mechanism underlying this phenomenon is still unclear. We report now that contralateral thalamic cannabinoid CB1 receptors are upregulated after unilateral axotomy of the tibial branch of the sciatic nerve, a rat model of chronic neuropathic pain, and hypothesize that cannabinoid CB1 receptor upregulation contributes to the increased analgesic efficacy of cannabinoids in chronic pain conditions. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：R5 / R7

页数：3

共 9 条

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