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Association between paternally inherited Haplotypes upstream of the insulin gene and umbilical cord IGF-II levels

被引：6
作者：
Adkins, Ronald M.
Fain, John N.
Krushkal, Julia
Klauser, Chad K.
Magann, Everett F.
Morrison, John C.
机构：
[1] Lebonheur Childrens Hosp & Med Ctr, Memphis, TN 38103 USA
[2] Univ Tennessee, Hlth Sci Ctr, Dept Pediat, Dept Prevent Med,Dept Mol Sci, Memphis, TN 38103 USA
[3] Naval Med Ctr Porstmouth, Dept Obstet & Gynecol, Portsmouth, VA 23708 USA
[4] Univ Mississippi, Med Ctr, Jackson, MS 39216 USA
来源：
PEDIATRIC RESEARCH | 2007年 / 62卷 / 04期
关键词：
D O I：
10.1203/PDR.0b013e3181425841
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The insulin (INS) and IGF 2 (IGF2) genes are in close proximity to each other and undergo maternal imprinting during fetal growth. We investigated the association between maternal and umbilical cord IGF 2 protein (IGF-II) levels and single nucleotide polymorphisms (SNPs) in the INS and IGF2 genes in 207 healthy African-American mother-newborn pairs. No association was found between maternal IGF-II levels and polymorphism in the INS-IGF2 locus. A significant association was found between newborn IGF-II levels and two SNPs (rs3842738 and rs689) at the 5' end of the INS-IGF2 focus. Analyses of haplotypes inferred from these two SNPs demonstrate a significant relationship between paternally transmitted haplotypes and newborn IGF-II levels, but no association with maternally transmitted haplotypes.
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收藏
页码：451 / 455
页数：5
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