The incurable wound revisited: progress in human rabies prevention?

被引：32

作者：

Hanlon, CA ^{[1
]}

Niezgoda, M ^{[1
]}

Morrill, PA ^{[1
]}

Rupprecht, CE ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Rabies Sect MS G33, Atlanta, GA 30333 USA

来源：

VACCINE | 2001年 / 19卷 / 17-19期

关键词：

rabies; immune globulin; lyssaviruses;

D O I：

10.1016/S0264-410X(00)00516-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rabies is the most important viral zoonosis from a global perspective. Modern human postexposure prophylaxis consists of potent vaccines and local infiltration of rabies immune globulins (RIGs), but the latter biologicals are not widely available or affordable. Monoclonal antibodies (Mabs) offer several theoretical advantages over RIGs. To this end, several human and equine RIGS. alone or in combination with vaccine, were investigated for postexposure efficacy in a Syrian hamster model, compared with a single neutralizing murine Mab. Preliminary results suggest that: (1) animal models continue to provide utility as human surrogates in the demonstration of product efficacy against rabies; (2) RIG preparations differ substantially in experimental effectiveness and clearance; and (3) relevant alternatives, such as Mabs, should be pursued for future improvements to human rabies prevention. Published by Elsevier Science Ltd.

引用

页码：2273 / 2279

页数：7

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