Skin permeability data: anomalous results

被引：54

作者：

Degim, IT ^{[1
]}

Pugh, WJ ^{[1
]}

Hadgraft, J ^{[1
]}

机构：

[1] Univ Wales Coll Cardiff, Welsh Sch Pharm, Cardiff CF1 3XF, S Glam, Wales

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1998年 / 170卷 / 01期

关键词：

skin permeability; prediction; transdermal; skin absorption;

D O I：

10.1016/S0378-5173(98)00113-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Analysis of published skin permeation data has shown that a few compounds appear to have anomalous skin permeability coefficients. These include penetrants such as naproxen, atropine and nicotine. The permeabilities of these materials were re-determined together with aspirin, benzoic acid, diclofenac, ibuprofen and methyl nicotinate. The results are discussed in conjunction with published regression analyses and compared with values predicted by estimating the octanol-water partition coefficients using commercial software packages. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：129 / 133

页数：5

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