The anticoagulant protein C pathway

被引：212

作者：

Dahlbäck, B

Villoutreix, BO

机构：

[1] Univ Lund Hosp, Wallenberg Lab, Dept Lab Med, SE-20502 Malmo, Sweden

[2] Univ Paris 05, INSERM, U648, F-75006 Paris, France

来源：

FEBS LETTERS | 2005年 / 579卷 / 15期

关键词：

factor V; protein C; protein S; thrombomodulin;

D O I：

10.1016/j.febslet.2005.03.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The anticoagulant protein C system regulates the activity of coagulation factors VIIIa and Va, cofactors in the activation of factor X and prothrombin, respectively. Protein C is activated on endothelium by the thrombin-thrombomodulin-EPCR (endothelial protein C receptor) complex. Activated protein C (APC)-mediated cleavages of factors Villa and Va occur on negatively charged phospholipid membranes and involve protein cofactors, protein S and factor V. APC also has anti-inflammatory and anti-apoptotic activities that involve binding of APC to EPCR and cleavage of PAR-1 (protease-activated receptor-1). Genetic defects affecting the protein C system are the most common risk factors of venous thrombosis. The protein C system contains multi-domain proteins, the molecular recognition of which will be reviewed. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：3310 / 3316

页数：7

共 56 条

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