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Effects of oligofructose on glucose and lipid metabolism in patients with nonalcoholic steatohepatitis: results of a pilot study

被引：128
作者：
Daubioul, CA
Horsmans, Y
Lambert, P
Danse, E
Delzenne, NM
机构：
[1] Catholic Univ Louvain, Unit Pharmacokinet Metab Nutr & Toxicol, B-1200 Brussels, Belgium
[2] Catholic Univ Louvain, Clin Univ St Luc, Gastroenterol Unit, B-1200 Brussels, Belgium
[3] Catholic Univ Louvain, Inst Stat, B-1348 Louvain, Belgium
来源：
EUROPEAN JOURNAL OF CLINICAL NUTRITION | 2005年 / 59卷 / 05期
关键词：
nonalcoholic steatohepatitis; humans; fructans; triacylglycerol; blood glucose; aminotransferases;
D O I：
10.1038/sj.ejcn.1602127
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Objective: In experimental animals, recent results suggest that the addition of inulin-type fructans such as oligofructose (OFS) in the diet decreases triacylglycerol accumulation in the liver tissue. Therefore, we have investigated the effect of daily ingestion of OFS in seven patients with nonalcoholic steatohepatitis (NASH), confirmed by liver biopsies. Design: They received 16 g/day OFS or maltodextrine ( placebo) for 8 weeks in a randomized double-blind crossover design. Energy intake, body composition, liver steatosis and blood parameters were analysed after 4 and 8 weeks of dietary supplementation. Results: Compared to placebo, OFS decreased significantly serum aminotransferases, aspartate aminotransferase after 8 weeks, and insulin level after 4 weeks, but this could not be related to significant effect on plasma lipids. Conclusion: This pilot study supports the putative interest of OFS in the management of liver diseases associated with abnormal lipid accumulation in humans.
引用
收藏
页码：723 / 726
页数：4
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