The Chromosome 6 sequencing project at the Sanger Centre

被引：8

作者：

Avis, T ^{[1
]}

Clark, EK ^{[1
]}

Flack, TL ^{[1
]}

Mohammadi, M ^{[1
]}

Milne, S ^{[1
]}

Niblett, D ^{[1
]}

Palmer, S ^{[1
]}

Phillips, S ^{[1
]}

Smalley, C ^{[1
]}

Tagney, M ^{[1
]}

Thorpe, KL ^{[1
]}

Tubby, B ^{[1
]}

Westhorp, J ^{[1
]}

Beck, S ^{[1
]}

机构：

[1] Sanger Ctr, Hinxton CB10 1SA, England

来源：

DNA SEQUENCE | 1997年 / 8卷 / 03期

基金：

英国惠康基金;

关键词：

Chromosome; 6; DNA sequencing; human genome project;

D O I：

10.3109/10425179709034062

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Chromosome 6 is probably best known for encoding the major histocompatibility complex (MHC) which is essential to the human immune response. In addition, it has been shown to be associated with many diseases such Schizophrenia, Diabetes, Arthritis, Haemochromatosis, Narcolepsy, Epilepsy, Retinitis Pigmentosa, Deafness, Ovarian Cancer, and many more. Chromosome 6 is about 180 Mb in size and is estimated to encode around 3500 genes of which only about 10% are currently known. It is our aim to map, sequence and annotate the entire chromosome in close collaboration with the chromosome 6 community.

引用

页码：131 / +

页数：6

共 6 条

[1] Evolutionary dynamics of non-coding sequences within the class II region of the human MHC [J].