High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[({2-[(5-iodopyridin-2-yl)amino]-ethyl}amino)-acetyl]-2-cyano-(S)-pyrrolidine

被引：86

作者：

Oefner, C ^{[1
]}

D'Arcy, A ^{[1
]}

Mac Sweeney, A ^{[1
]}

Pierau, S ^{[1
]}

Gardiner, R ^{[1
]}

Dale, GE ^{[1
]}

机构：

[1] Morphochem AG, Basel, Switzerland

来源：

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY | 2003年 / 59卷

关键词：

D O I：

10.1107/S0907444903010059

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Dipeptidyl peptidase IV is a multifunctional type II transmembrane serine protease glycoprotein. The high-resolution crystal structure of the homodimeric human apo dipeptidyl peptidase IV has been determined at 1.9 Angstrom resolution. In addition, the structure of the binary complex with 1-[({2[(5-iodopyridin-2-yl)amino]-ethyl}amino)-acetyl]-2-cyano-(S)-pyrrolidine has been solved, revealing the nature of the covalent interaction with the active-site serine.

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页码：1206 / 1212

页数：7

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