Pathogenicity of an enterotoxigenic Escherichia coli hemolysin (hlyA) mutant in gnotobiotic piglets

被引：30

作者：

Moxley, RA

Berberov, EM

Francis, DH

Xing, J

Moayeri, M

Welch, RA

Baker, DR

Barletta, RG

机构：

[1] Univ Nebraska, Dept Vet Sci, Lincoln, NE 68583 USA

[2] Univ Nebraska, Dept Biomed Sci, Lincoln, NE 68583 USA

[3] Univ Wisconsin, Dept Med Microbiol & Immunol, Madison, WI 53706 USA

[4] S Dakota State Univ, Dept Vet Sci, Brookings, SD 57007 USA

来源：

INFECTION AND IMMUNITY | 1998年 / 66卷 / 10期

关键词：

D O I：

10.1128/IAI.66.10.5031-5035.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pigs infected with hemolytic F4(+) strains of enterotoxigenic Escherichia coli often develop septicemia secondary to intestinal infection. We tested the hypothesis that inactivation of hemolysin would reduce the ability of F4+ enterotoxigenic E. coli to cause septicemia in swine following oral inoculation. Inactivation of the hemolysin structural gene (hlyA) did not decrease the incidence of septicemia in the gnotobiotic piglet model.

引用

页码：5031 / 5035

页数：5

共 45 条

[1] Distribution of K88 Escherichia coli adhesive and nonadhesive phenotypes among pigs of four breeds [J].