Walking the Walk from Genes through Telomere Maintenance to Cancer Risk

被引：20

作者：

Blackburn, Elizabeth H. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA

来源：

CANCER PREVENTION RESEARCH | 2011年 / 4卷 / 04期

关键词：

GENOME-WIDE ASSOCIATION; CORONARY-HEART-DISEASE; LENGTH; LOCUS; PREVENTION;

D O I：

10.1158/1940-6207.CAPR-11-0066

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Recent studies have shown associations between human population single-nucleotide polymorphisms (SNP) and white blood cell telomere shortness; independently, telomere shortness has been associated with higher risks of various cancers. However, no single previous study simultaneously linked a given SNP both with telomere length and reduced risk of cancer. In this issue of the journal (beginning on page 514), Gu and colleagues report four new SNPs associated, in three cohorts, with telomere length. One of these SNPs predicted risk for bladder cancer, an effect partially mediated by telomere length. Interventions that could forestall telomere shortening should be explored for their potential to reduce cancer risks. Cancer Prev Res; 4(4); 473-5. (C) 2011 AACR.

引用

页码：473 / 475

页数：3

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