Increased karyotype precision using fluorescence in situ hybridization and spectral karyotyping in patients with myeloid malignancies

被引：25

作者：

Fleischman, EW

Reshmi, S

Sokova, OI

Kirichenko, OP

Konstantinova, LN

Kulagina, OE

Frenkel, MA

Rowley, JD

机构：

[1] Univ Chicago, Dept Med, Hematol Oncol Sect, Chicago, IL 60637 USA

[2] Russian Acad Med Sci, Canc Res Ctr, Moscow, Russia

来源：

CANCER GENETICS AND CYTOGENETICS | 1999年 / 108卷 / 02期

关键词：

D O I：

10.1016/S0165-4608(98)00137-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We studied seven patients with various malignant hematologic disorders using fluorescence in situ hybridization (FISH) and one of these patients with spectral karyotyping (SKY). With appropriate probes, the t(8;21) and inv(16) were confirmed in two patients and the karyotypic precision was increased in five others using FISH and SKY. Two of three patients with 12p rearrangements had a deletion of one TEL allele. Thus, these newer techniques ore an important adjunct to accurate chromosome analysis in malignancy. (C) Elsevier Science Inc., 1998.

引用

页码：166 / 170

页数：5

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