Peroxisome proliferator-activated receptor-γ:: from adipogenesis to carcinogenesis

被引：194

作者：

Fajas, L ^{[1
]}

Debril, MB ^{[1
]}

Auwerx, J ^{[1
]}

机构：

[1] Univ Strasbourg 1, CNRS, INSERM, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France

来源：

JOURNAL OF MOLECULAR ENDOCRINOLOGY | 2001年 / 27卷 / 01期

关键词：

D O I：

10.1677/jme.0.0270001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors, initially described as molecular targets for synthetic compounds inducing peroxisome proliferation. PPAR-gamma, the best characterized of the PPARs, plays a crucial role in adipogenesis and insulin sensitization. Furthermore, PPAR-gamma has been reported to affect cell proliferation/differentiation pathways in various malignancies. We discuss in the present review recent advances in the understanding of the function of PPAR-gamma in both cell proliferation and adipocyte differentiation.

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页码：1 / 9

页数：9

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