Evaluation of a rapid, real-time intrapartum group B streptococcus assay

被引：39

作者：

Young, Brett C. ^{[1
,3
]}

Dodge, Laura E. ^{[1
]}

Gupta, Munish ^{[2
,4
]}

Rhee, Julie S. ^{[1
,3
]}

Hacker, Michele R. ^{[1
,3
]}

机构：

[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Obstet & Gynecol, Boston, MA 02215 USA

[2] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Neonatol, Boston, MA 02215 USA

[3] Harvard Univ, Dept Obstet Gynecol & Reprod Biol, Sch Med, Boston, MA 02215 USA

[4] Harvard Univ, Dept Pediat, Sch Med, Boston, MA 02215 USA

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2011年 / 205卷 / 04期

关键词：

group B streptococcus; intrapartum assay; intrapartum screening; neonatal sepsis; COLONIZATION; ACCURACY; DISEASE;

D O I：

10.1016/j.ajog.2011.06.087

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: We sought to evaluate an intrapartum nucleic acid amplification test (NAAT) for group B streptococcus (GBS). STUDY DESIGN: This was a prospective cohort study of 559 women comparing intrapartum GBS culture with antepartum culture and intrapartum NAAT. RESULTS: GBS prevalence was 19.5% by antepartum culture and 23.8% by intrapartum culture. Compared with intrapartum culture, antepartum culture had 69.2% sensitivity (60.6-76.9%) and 96.0% specificity (93.7-97.7%). The NAAT demonstrated sensitivity of 90.8% (84.6-95.2%), specificity of 97.6% (95.6-98.8%), and predictive values >92%. The incidence of discordant cultures was 10.4%. Of the women with negative antepartum and positive intrapartum cultures, only 1 (2.4%) received intrapartum antibiotics. Compared with white women, black (P = .02) and Hispanic (P = .02) women were more likely to have discordant cultures. CONCLUSION: This intrapartum NAAT has excellent characteristics. It may be superior to antepartum culture for detecting intrapartum GBS-allowing more accurate management of laboring mothers and reducing neonatal GBS sepsis.

引用

页码：372.e1 / 372.e6

页数：6

共 16 条

[1] Multicenter study of a rapid molecular-based assay for the diagnosis of group B Streptococcus colonization in pregnant women [J].