Linkage information content of polymorphic genetic markers

被引：104

作者：

Guo, XQ ^{[1
]}

Elston, RC ^{[1
]}

机构：

[1] Case Western Reserve Univ, Rammelkamp Ctr Educ & Res, Dept Epidemiol & Biostat, Cleveland, OH 44109 USA

来源：

HUMAN HEREDITY | 1999年 / 49卷 / 02期

关键词：

PIC value; marker polymorphism; model-free linkage analysis; sib pairs;

D O I：

10.1159/000022855

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The Polymorphism Information Content (PIC) value is often used to measure the informativeness of a genetic marker for linkage studies. The PIC value was first derived for the case of a rare dominant disease, when one of the parents is affected, and is a function of the particular mode of disease inheritance. We first generalize the definition of the PIC value in such a way that it does not depend on the mode of inheritance of the trait being studied, and then develop a Linkage Information Content (LIC) value to measure the informativeness of a marker about the identity-by-descent sharing status of particular types of pairs of relatives. Knowing the LIC value, it is possible to determine the effective number of fully informative pairs in a study when we have incomplete marker information.

引用

页码：112 / 118

页数：7