Cellular cardiomyoplasty: Clinical application

被引：75

作者：

Chachques, JC ^{[1
]}

Acar, C ^{[1
]}

Herreros, J ^{[1
]}

Trainini, JC ^{[1
]}

Prosper, F ^{[1
]}

D'Attellis, N ^{[1
]}

Fabiani, JN ^{[1
]}

Carpentier, AF ^{[1
]}

机构：

[1] Univ Paris, Dept Cardiovasc Surg, European Hosp Georges Pompidou, F-75015 Paris, France

来源：

ANNALS OF THORACIC SURGERY | 2004年 / 77卷 / 03期

关键词：

D O I：

10.1016/j.athoracsur.2003.09.081

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Myocardial regeneration can be induced with the implantation of a variety of myogenic and angiogenic cell types. More than 150 patients have been treated with cellular cardiomyoplasty worldwide, 18 patients have been treated by our group. Cellular cardiomyoplasty seems to reduce the size and fibrosis of infarct scars, limit postischemic remodelling, and restore regional myocardial contractility. Techniques for skeletal myoblasts culture and ex vivo expansion using autologous patient serum (obtained from plasmapheresis) have been developed by our group. In this article we propose (1) a total autologous cell culture technique and procedures for cell delivery and (2) a clinical trial with appropriate end-points structured to determine the efficacy of cellular cardiomyoplasty. (C) 2004 by The Society of Thoracic Surgeons.

引用

页码：1121 / 1130

页数：10

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