Control of gastric acid secretion in health and disease

被引：335

作者：

Schubert, Mitchell L. ^{[1
]}

Peura, David A. ^{[2
]}

机构：

[1] Virginia Commonwealth Univ, Div Gastroenterol, Dept Med, McGuire VAMC,Med Coll Virginia, Richmond, VA 23249 USA

[2] Univ Virginia, Dept Med, Div Gastroenterol & Hepatol, Charlottesville, VA USA

来源：

GASTROENTEROLOGY | 2008年 / 134卷 / 07期

关键词：

D O I：

10.1053/j.gastro.2008.05.021

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Recent milestones in the understanding of gastric acid secretion and treatment of acid-peptic disorders include the (1) discovery of histamine H-2-receptors and development of histamine H-2-receptor antagonists, (2) identification of H+K+-ATPase as the parietal cell proton pump and development of proton pump inhibitors, and (3) identification of Helicobacter pylori as the major cause of duodenal ulcer and development of effective eradication regimens. This review emphasizes the importance and relevance of gastric acid secretion and its regulation in health and disease. We review the physiology and pathophysiology of acid secretion as well as evidence regarding its inhibition in the management of acid-related clinical conditions.

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页码：1842 / 1860

页数：19

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