From RNA helicases to RNPases

被引：52

作者：

Linder, P ^{[1
]}

Tanner, NK ^{[1
]}

Banroques, J ^{[1
]}

机构：

[1] Ctr Med Univ, Dept Biochim Med, CH-1211 Geneva, Switzerland

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2001年 / 26卷 / 06期

关键词：

D O I：

10.1016/S0968-0004(01)01870-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In eukaryotic cells, all aspects of cellular RNA metabolism require putative RNA helicases of the DEAD and DExH protein families (collectively known as DExD/H families). Based on data from biochemical studies of a few of these RNA helicases, they are generally considered to be involved in the unwinding of duplex RNA molecules. However, recent reports provide evidence indicating that these proteins might also be involved in the active disruption of RNA-protein interactions.

引用

页码：339 / 341

页数：3

共 15 条

[1] THE HUMAN U1 SNRNP-SPECIFIC U1A PROTEIN INHIBITS POLYADENYLATION OF ITS OWN PREMESSENGER RNA [J].

BOELENS, WC ;

JANSEN, EJR ;

VANVENROOIJ, WJ ;

STRIPECKE, R ;

MATTAJ, IW ;

GUNDERSON, SI .

CELL, 1993, 72 (06) :881-892

[2] BEAT THE CLOCK - PARADIGMS FOR NTPASES IN THE MAINTENANCE OF BIOLOGICAL FIDELITY [J].

BURGESS, SM ;

GUTHRIE, C .

TRENDS IN BIOCHEMICAL SCIENCES, 1993, 18 (10) :381-384

[3] Specific alterations of U1-C protein or U1 small nuclear RNA can eliminate the requirement of Prp28p, an essential DEAD box splicing factor [J].

Chen, JYF ;

Stands, L ;

Staley, JP ;

Jackups, RR ;

Latus, LJ ;

Chang, TH .

MOLECULAR CELL, 2001, 7 (01) :227-232

[4] Unwinding RNA in Saccharomyces cerevisiae:: DEAD-box proteins and related families [J].

de la Cruz, J ;

Kressler, D ;

Linder, P .

TRENDS IN BIOCHEMICAL SCIENCES, 1999, 24 (05) :192-198

[5] INTERACTION OF RNA HAIRPINS WITH THE HUMAN U1A N-TERMINAL RNA-BINDING DOMAIN [J].

HALL, KB .

BIOCHEMISTRY, 1994, 33 (33) :10076-10088

[6] Helicase motifs: the engine that powers DNA unwinding [J].

Hall, MC ;

Matson, SW .

MOLECULAR MICROBIOLOGY, 1999, 34 (05) :867-877

[7] The DExH protein NPH-II is a processive and directional motor for unwinding RNA [J].

Jankowsky, E ;

Gross, CH ;

Shuman, S ;

Pyle, AM .

NATURE, 2000, 403 (6768) :447-451

[8] Active disruption of an RNA-protein interaction by a DExH/D RNA helicase [J].

Jankowsky, E ;

Gross, CH ;

Shuman, S ;

Pyle, AM .

SCIENCE, 2001, 291 (5501) :121-125

[9] Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for Sub2, an essential spliceosomal ATPase [J].

Kistler, AL ;

Guthrie, C .

GENES & DEVELOPMENT, 2001, 15 (01) :42-49

[10] The DEAD box protein eIF4A. 1. A minimal kinetic and thermodynamic framework reveals coupled binding of RNA and nucleotide [J].

Lorsch, JR ;

Herschlag, D .

BIOCHEMISTRY, 1998, 37 (08) :2180-2193

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