Synergistic effects of transforming growth factor-beta on the expression of c-fms, macrophage colony-stimulating factor receptor gene, in vascular smooth muscle cells

被引：6

作者：

Inaba, T ^{[1
]}

Ishibashi, S ^{[1
]}

Harada, K ^{[1
]}

Osuga, J ^{[1
]}

Yagyu, H ^{[1
]}

Ohashi, K ^{[1
]}

Yazaki, Y ^{[1
]}

Yamada, N ^{[1
]}

机构：

[1] UNIV TOKYO,FAC MED,DEPT INTERNAL MED 3,BUNKYO KU,TOKYO 113,JAPAN

来源：

FEBS LETTERS | 1996年 / 399卷 / 03期

关键词：

vascular smooth muscle cell; atherosclerosis; macrophage colony-stimulating factor; transforming growth factor-beta; platelet-derived growth factor;

D O I：

10.1016/S0014-5793(96)01322-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vascular smooth muscle cells (SMC) transform to foam cells in the process of atherosclerosis, We have reported that SMC derived from the intima of atherosclerotic lesions express c-fms, macrophage colony-stimulating factor receptor gene, which is not normally expressed in medial SMC, In the present study, we demonstrated that transforming growth factor-beta (TGF-beta) synergistically induced expression of c-fms in the presence of platelet-derived growth factor-BB in human medial SMC, a level comparable to that observed in the intima, The induction of c-fms was not inhibited by protein kinase C (PKC) inhibitor, suggesting that TGF-beta induces c-fms via a PKC-independent pathway, These results suggest that TGF-beta plays an important role in the phenotypic change of smooth muscle cells to macrophage-like cells in the process of atherosclerosis.

引用

页码：207 / 210

页数：4

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