Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1

被引：21

作者：

Niiro, H

Clark, EA ^{[1
]}

机构：

[1] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA

[2] Univ Washington, Dept Immunol, Seattle, WA 98195 USA

来源：

IMMUNITY | 2003年 / 19卷 / 05期

关键词：

D O I：

10.1016/S1074-7613(03)00303-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Adaptor proteins act as conduits to channel upstream signals into downstream effector branches. Two. B cell-associated adaptors, Bam32 and Carma1, regulate the ERK, JNK, and NF-kappaB branches of the BCR signaling pathway. Recent studies of Bam32(-/-) and Carma1(-/-) mice suggest that each adaptor controls a distinct conduit regulating either only proliferation (Bam32) or both the proliferation and survival of B cells (Carma1).

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页码：637 / 640

页数：4

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