Clinical Efforts to Reduce Myocardial Infarct Size-The Next Step

被引：15

作者：

Braunwald, Eugene ^{[1
,2
]}

机构：

[1] Brigham & Womens Hosp, TIMI Study Grp, Dept Med, Div Cardiovasc, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Med, Boston, MA USA

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS | 2011年 / 16卷 / 3-4期

关键词：

reperfusion; myocardial infarction; ischemic injury; mitochondria; CORONARY-ARTERY REPERFUSION; NO-REFLOW PHENOMENON; PRECONDITIONING PROTECTS; CONTROLLED-TRIAL; CARDIAC-SURGERY; ISCHEMIA; INJURY; ADENOSINE; THERAPY; HEART;

D O I：

10.1177/1074248411407637

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Prompt myocardial reperfusion reduces infarct size in patients experiencing coronary occlusion. However, its clinical value is limited because reperfusion also causes ischemic myocardial reperfusion injury (IMRI). Considerable research to reduce IMRI has been conducted. Three interventions appear to be promising: 1) myocardial conditioning, which consists of repetitive occlusions of coronary or other arteries prior to or at the time of myocardial reperfusion; 2) the administration of cyclosporine A; and 3) the administration of adenosine. A plan for the testing of these interventions in patients with acute myocardial infarction is described.

引用

页码：349 / 353

页数：5

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