Comparative genomic hybridisation identifies two variants of smoldering multiple myeloma

被引：32

作者：

Rosiñol, L

Carrió, A

Bladé, J

Queralt, R

Aymerich, M

Cibeira, MT

Esteve, J

Rozman, M

Campo, E

Montserrat, E

机构：

[1] Univ Barcelona, IDIBAPS, Dept Hematol, Inst Hematol & Oncol,Hosp Clin Barcelona, E-08036 Barcelona, Spain

[2] Univ Barcelona, IDIBAPS, Haematopathol Dept, Hosp Clin Barcelona, E-08036 Barcelona, Spain

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2005年 / 130卷 / 05期

关键词：

smoldering multiple myeloma; comparative genomic hybridisation; multiple myeloma; prognosis; transformation;

D O I：

10.1111/j.1365-2141.2005.05673.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Two variants of smoldering multiple myeloma (SMM) have been recognised: (i) an evolving type, characterised by a progressive increase in the M-protein size and short time to progression to overt multiple myeloma (MM) and (ii) a non-evolving type, with a long-lasting, stable M-protein and longer time to progression. Comparative genomic hybridisation (CGH) analyses in both subtypes of SMM (seven evolving and eight non-evolving SMM) were performed. Evolving SMM showed cytogenetic changes consistent with those found in de novo symptomatic MM (1q gains, chromosome 13 deletions) while the non-evolving variant showed no 1q gains and deletions were uncommon.

引用

页码：729 / 732

页数：4

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