Role of ErbB4 in breast cancer

被引：112

作者：

Sundvall, Maria ^{[1
,2
]}

Iljin, Kristiina ^{[3
]}

Kilpinen, Sami ^{[4
,5
]}

Sara, Henri ^{[6
,7
]}

Kallioniemi, Olli-Pekka ^{[3
,4
,5
,6
,7
]}

Elenius, Klaus ^{[1
,2
,8
]}

机构：

[1] Univ Turku, Dept Med Biochem & Mol Biol, FIN-20520 Turku, Finland

[2] Univ Turku, Medic Res Lab, Turku, Finland

[3] VTT Tech Res Ctr, Turku, Finland

[4] FIMM Inst Mol Med Finland, Helsinki, Finland

[5] Univ Helsinki, Genome Scale Biol Res Program, Biomedicum, Helsinki, Finland

[6] Univ Turku, Turku Ctr Biotechnol, Turku, Finland

[7] Univ Turku, Turku Ctr Biotechnol, Abo Acad Univ, Turku, Finland

[8] Turku Univ, Cent Hosp, Dept Oncol, Turku, Finland

来源：

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA | 2008年 / 13卷 / 02期

关键词：

alternative splicing; epidermal growth factor; estrogen receptor; HER4; neuregulins; targeted therapeutics;

D O I：

10.1007/s10911-008-9079-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Members of the ErbB subfamily of receptor tyrosine kinases are important regulators of normal mammary gland physiology, and aberrations in their signaling have been associated with breast tumorigenesis. Therapeutics targeting epidermal growth factor receptor (EGFR = ErbB1) or ErbB2 in breast cancer have been approved for clinical use. In contrast, relatively little is known about the biological significance of ErbB4 signaling in breast cancer. This review focuses on recent advances in our understanding about the role of ErbB4 in breast carcinogenesis, as well as in the potential clinical relevance of ErbB4 in breast cancer prognostics and therapy.

引用

页码：259 / 268

页数：10

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