Time course of transient expression of GDNF protein in rat granule cells of the bilateral dentate gyri after unilateral intrahippocampal kainic acid injection

被引：15

作者：

Mikuni, N

Babb, TL

Chakravarty, DN

Christi, W

机构：

[1] Cleveland Clin Fdn, Dept Neurosci, Cleveland, OH 44195 USA

[2] Cleveland Clin Fdn, Dept Neurol, Cleveland, OH 44195 USA

来源：

NEUROSCIENCE LETTERS | 1999年 / 262卷 / 03期

关键词：

glial cell line-derived neurotrophic factor; rat; dentate gyrus; kainic acid; granule cells; seizure;

D O I：

10.1016/S0304-3940(99)00074-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the time course of expression of glial cell line-derived neurotrophic factor (GDNF) protein in the granule cells of the dentate gyrus following unilateral intrahippocampal injection of kainic acid (KA). Recurrent behavioral seizures were observed approximately 1 h after KA injection, which lasted for 4-6 h. GDNF immunoreactivity began to increase bilaterally in the granule cells within 3 h after KA injection, continued to increase until post-injection day (PID) 4, and returned to the control level by PID 7. The results suggest that the increase of GDNF protein in the granule cells may be ascribable to seizures induced by the KA injection. The increase of GDNF protein might promote survival of the granule cells after the intrahippocampal KA injection. (C) 1999 Published by Elsevier Science Ireland Ltd. Alt rights reserved.

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页码：215 / 218

页数：4

相关论文

共 19 条

[1] GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo [J].

Arenas, E ;

Trupp, M ;

Akerud, P ;

Ibanez, CF .

NEURON, 1995, 15 (06) :1465-1473

[2] Glutamate AMPA receptors in the fascia dentata of human and kainate rat hippocampal epilepsy [J].

Babb, TL ;

Mathern, GW ;

Leite, JP ;

Pretorius, JK ;

Yeoman, KM ;

Kuhlman, PA .

EPILEPSY RESEARCH, 1996, 26 (01) :193-205

[3] GDNF signalling through the Ret receptor tyrosine kinase [J].

Durbec, P ;

MarcosGutierrez, CV ;

Kilkenny, C ;

Grigoriou, M ;

Wartiovaara, K ;

Suvanto, P ;

Smith, D ;

Ponder, B ;

Costantini, F ;

Saarma, M ;

Sariola, H ;

Pachnis, V .

NATURE, 1996, 381 (6585) :789-793

[4]

Gall C M, 1997, Adv Neurol, V72, P9

[5] GDNF - A POTENT SURVIVAL FACTOR FOR MOTONEURONS PRESENT IN PERIPHERAL-NERVE AND MUSCLE [J].

HENDERSON, CE ;

PHILLIPS, HS ;

POLLOCK, RA ;

DAVIES, AM ;

LEMEULLE, C ;

ARMANINI, M ;

SIMPSON, LC ;

MOFFET, B ;

VANDLEN, RA ;

KOLIATSOS, VE ;

ROSENTHAL, A .

SCIENCE, 1994, 266 (5187) :1062-1064

[6] NEURONS OF THE HIPPOCAMPAL-FORMATION EXPRESS GLIAL-CELL LINE-DERIVED NEUROTROPHIC FACTOR MESSENGER-RNA IN RESPONSE TO KAINATE-INDUCED EXCITATION [J].

HUMPEL, C ;

HOFFER, B ;

STROMBERG, I ;

BEKTESH, S ;

COLLINS, F ;

OLSON, L .

NEUROSCIENCE, 1994, 59 (04) :791-795

[7] GDNF - A GLIAL-CELL LINE DERIVED NEUROTROPHIC FACTOR FOR MIDBRAIN DOPAMINERGIC-NEURONS [J].

LIN, LFH ;

DOHERTY, DH ;

LILE, JD ;

BEKTESH, S ;

COLLINS, F .

SCIENCE, 1993, 260 (5111) :1130-1132

[8] DELAYED CELL-DEATH IN THE CONTRALATERAL HIPPOCAMPUS FOLLOWING KAINATE INJECTION INTO THE CA3 SUBFIELD [J].

MAGLOCZKY, Z ;

FREUND, TF .

NEUROSCIENCE, 1995, 66 (04) :847-860

[9] POTENT INHIBITORY EFFECTS OF GLIAL DERIVED NEUROTROPHIC FACTOR AGAINST KAINIC ACID-MEDIATED SEIZURES IN THE RAT [J].

MARTIN, D ;

MILLER, G ;

ROSENDAHL, M ;

RUSSELL, DA .

BRAIN RESEARCH, 1995, 683 (02) :172-178

[10] HIPPOCAMPAL EEG EXCITABILITY AND CHRONIC SPONTANEOUS SEIZURES ARE ASSOCIATED WITH ABERRANT SYNAPTIC REORGANIZATION IN THE RAT INTRAHIPPOCAMPAL KAINATE MODEL [J].

MATHERN, GW ;

CIFUENTES, F ;

LEITE, JP ;

PRETORIUS, JK ;

BABB, TL .

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1993, 87 (05) :326-339