Angiopoietin-2: Development of Inhibitors for Cancer Therapy

被引：136

作者：

Hu, Bo ^{[1
]}

Cheng, Shi-Yuan ^{[1
]}

机构：

[1] Univ Pittsburgh, Inst Canc, HCCLB, Pittsburgh, PA 15213 USA

来源：

CURRENT ONCOLOGY REPORTS | 2009年 / 11卷 / 02期

基金：

美国国家卫生研究院;

关键词：

ENDOTHELIAL-CELL SURVIVAL; MATRIX METALLOPROTEASE-2; RECEPTOR-BINDING; TIE2; RECEPTOR; EXPRESSION; ANGIOGENESIS; GROWTH; INTEGRIN; ADHESION; LIGAND;

D O I：

10.1007/s11912-009-0017-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Angiopoietin-2 (Ang2) is a member of the Ang family, which plays an important role in angiogenesis during the development and growth of human cancers. Ang2's role in angiogenesis generally is considered as an antagonist for Ang1, inhibiting Ang1-promoted Tie2 signaling, which is critical for blood vessel maturation and stabilization. Ang2 modulates angiogenesis in a cooperative manner with another important angiogenic factor, vascular endothelial growth factor A. Genetic studies have revealed that Ang2 also is critical in lymphangiogenesis during development. However, new evidence suggests more complicated roles for Ang2 in angiogenesis in physiologic processes and invasive phenotypes of cancer cells during progression of human cancers. This article discusses recent studies of Ang2 in angiogenesis and the implication of Ang2 as a therapeutic target as well as a potential inhibitor for antiangiogenesis treatment for cancer patients.

引用

页码：111 / 116

页数：6

共 49 条

[1]

Angiopoietins in malignancy [J].

Bach, F. ;

Uddin, F. J. ;

Burke, D. .

EJSO, 2007, 33 (01) :7-15

[2]

Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth [J].

Cao, Yiting ;

Sonveaux, Pierre ;

Liu, Shanling ;

Zhao, Yulin ;

Mi, Jing ;

Clary, Bryan M. ;

Li, Chuan-Yuan ;

Kontos, Christopher D. ;

Dewhirst, Mark W. .

CANCER RESEARCH, 2007, 67 (08) :3835-3844

[3]

Direct cell adhesion to the angiopoietins mediated by integrins [J].

Carlson, TR ;

Feng, YZ ;

Maisonpierre, PC ;

Mrksich, M ;

Morla, AO .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (28) :26516-26525

[4]

Angiogenesis in cancer and other diseases [J].

Carmeliet, P ;

Jain, RK .

NATURE, 2000, 407 (6801) :249-257

[5]

Stable interaction between α5β1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1 [J].

Cascone, I ;

Napione, L ;

Maniero, F ;

Serini, G ;

Bussolino, F .

JOURNAL OF CELL BIOLOGY, 2005, 170 (06) :993-1004

[6]

Long-term and sustained COMP-Ang1 induces long-lasting vascular enlargement and enhanced blood flow [J].

Cho, CH ;

Kim, KE ;

Byun, J ;

Jang, HS ;

Kim, DK ;

Baluk, P ;

Baffert, F ;

Lee, GM ;

Mochizuki, N ;

Kim, J ;

Jeon, BH ;

McDonald, DM ;

Koh, GY .

CIRCULATION RESEARCH, 2005, 97 (01) :86-94

[7]

Leptin induces angiopoietin-2 expression in adipose tissues [J].

Cohen, B ;

Barkan, D ;

Levy, Y ;

Goldberg, I ;

Fridman, E ;

Kopolovic, J ;

Rubinstein, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (11) :7697-7700

[8]

Angiopoietin-1 promotes cardiac and skeletal myocyte survival through integrins [J].

Dallabrida, SM ;

Ismail, N ;

Oberle, JR ;

Himes, BE ;

Rupnick, MA .

CIRCULATION RESEARCH, 2005, 96 (04)

[9]

Isolation of Angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning [J].

Davis, S ;

Aldrich, TH ;

Jones, PF ;

Acheson, A ;

Compton, DL ;

Jain, V ;

Ryan, TE ;

Bruno, J ;

Radziejewski, C ;

Maisonpierre, PC ;

Yancopoulos, GD .

CELL, 1996, 87 (07) :1161-1169

[10]

Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering [J].

Davis, S ;

Papadopoulos, N ;

Aldrich, TH ;

Maisonpierre, PC ;

Huang, T ;

Kovac, L ;

Xu, A ;

Leidich, R ;

Radziejewska, E ;

Rafique, A ;

Goldberg, J ;

Jain, V ;

Bailey, K ;

Karow, M ;

Fandl, J ;

Samuelsson, SJ ;

Ioffe, E ;

Rudge, JS ;

Daly, TJ ;

Radziejewski, C ;

Yancopoulos, GD .

NATURE STRUCTURAL BIOLOGY, 2003, 10 (01) :38-44

← 1 2 3 4 5 →