Dynamic contrast-enhanced magnetic resonance imaging and pharmacokinetic models in prostate cancer

被引：98

作者：

Franiel, Tobias ^{[1
,2
]}

Hamm, Bernd ^{[3
]}

Hricak, Hedvig ^{[2
]}

机构：

[1] Charite, Inst Radiol, D-10117 Berlin, Germany

[2] Mem Sloan Kettering Canc Ctr, Dept Radiol, New York, NY 10021 USA

[3] Charite, Dept Radiol, D-10117 Berlin, Germany

来源：

EUROPEAN RADIOLOGY | 2011年 / 21卷 / 03期

关键词：

Prostate; DCE-MRI; Pharmacokinetic parameters; Blood flow; Permeability; EXTERNAL-BEAM RADIOTHERAPY; ARTERIAL INPUT FUNCTION; GRADIENT-ECHO SEQUENCE; RADICAL PROSTATECTOMY; RADIATION-THERAPY; LOCAL RECURRENCE; GD-DTPA; MICROVESSEL DENSITY; MICROVASCULAR PERMEABILITY; ACTIVE SURVEILLANCE;

D O I：

10.1007/s00330-010-2037-7

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Dynamic contrast-enhanced MRI enables noninvasive analysis of prostate vascularization as well as tumour angiogenesis and capillary permeability characteristics in prostate cancers. Pharmacokinetic models summarizing the complex information provided by signal intensity-time curves for a few quantitative pharmacokinetic parameters are increasingly being used in the routine clinical setting. This review consists of two parts. The first part discusses the advantages and disadvantages of the MR pulse sequences that can be used for performing DCE-MRI and also of the most widely used pharmacokinetic parameters and models and the parameters they describe. The second part outlines the range of current and potential future clinical applications of DCE-MRI and pharmacokinetic parametric maps in patients with prostate cancer, with reference to the current scientific literature on the topic. The potential clinical applications of DCE-MRI for prostate cancer include detection, localization, and staging, differentiation of recurrent cancer and estimation of the patient's prognosis, as well as monitoring of treatment response.

引用

页码：616 / 626

页数：11

共 104 条

[1]

American Urological Association, 2007, GUID MAN CLIN LOC PR

[2] Evaluation of T2-weighted and dynamic contrast-enhanced MRI in localizing prostate cancer before repeat biopsy [J].

Ben Cheikh, Alexandre ;

Girouin, Nicolas ;

Colombel, Marc ;

Marechal, Jean-Marie ;

Gelet, Albert ;

Bissery, Alvine ;

Rabilloud, Muriel ;

Lyonnet, Denis ;

Rouviere, Olivier .

EUROPEAN RADIOLOGY, 2009, 19 (03) :770-778

[3] MRI of prostate cancer at 1.5 and 3.0 T:: Comparison of image quality in tumor detection and staging [J].

Beyersdorff, D ;

Taymoorian, K ;

Knösel, T ;

Schnorr, D ;

Felix, R ;

Hamm, B ;

Bruhn, H .

AMERICAN JOURNAL OF ROENTGENOLOGY, 2005, 185 (05) :1214-1220

[4] Patients with a history of elevated prostate-specific antigen levels and negative transrectal US-guided quadrant or sextant biopsy results: Value of MR imaging [J].

Beyersdorff, D ;

Taupitz, M ;

Winkelmann, B ;

Fischer, T ;

Lenk, S ;

Loening, SA ;

Hamm, B .

RADIOLOGY, 2002, 224 (03) :701-706

[5] COMPARISON OF MICROSCOPIC VASCULARITY IN BENIGN AND MALIGNANT PROSTATE TISSUE [J].

BIGLER, SA ;

DEERING, RE ;

BRAWER, MK .

HUMAN PATHOLOGY, 1993, 24 (02) :220-226

[6] Prostate cancer: Accurate determination of extracapsular extension with high-spatial-resolution dynamic contrast-enhanced and T2-weighted MR imaging - Initial results [J].

Bloch, B. Nicolas ;

Furman-Haran, Edna ;

Helbich, Thomas H. ;

Lenkinski, Robert E. ;

Degani, Hadassa ;

Kratzik, Christian ;

Susani, Martin ;

Haitel, Andrea ;

Jaromi, Silvia ;

Ngo, Long ;

Rofsky, Neil M. .

RADIOLOGY, 2007, 245 (01) :176-185

[7] Methods for quantitative assessment of tissue microcirculation using dynamic contrast-enhanced MR imaging [J].

Brix, G ;

Schreiber, W ;

Hoffmann, U ;

Guckel, F ;

Hawighorst, H ;

Knopp, MV .

RADIOLOGE, 1997, 37 (06) :470-480

[8] PHARMACOKINETIC PARAMETERS IN CNS GD-DTPA ENHANCED MR IMAGING [J].

BRIX, G ;

SEMMLER, W ;

PORT, R ;

SCHAD, LR ;

LAYER, G ;

LORENZ, WJ .

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1991, 15 (04) :621-628

[9] THE ROLE OF INTRAVENOUS CONTRAST ENHANCEMENT IN MAGNETIC-RESONANCE-IMAGING OF PROSTATIC-CARCINOMA [J].

BROWN, G ;

MACVICAR, DA ;

AYTON, V ;

HUSBAND, JE .

CLINICAL RADIOLOGY, 1995, 50 (09) :601-606

[10] Endorectal and dynamic contrast-enhanced MRI for detection of local recurrence after radical prostatectomy [J].

Casciani, Emanuele ;

Polettini, Elisabetta ;

Carmenini, Enrico ;

Floriani, Irene ;

Masselli, Gabriele ;

Bertini, Luca ;

Gualdi, Gian Franco .

AMERICAN JOURNAL OF ROENTGENOLOGY, 2008, 190 (05) :1187-1192

← 1 2 3 4 5 6 7 8 9 10 →