Formation and isolation of simple, stable, acyclic di- and tripeptide hemiacetals.

被引:10
作者
Miller, JF [1 ]
Spaltenstein, A [1 ]
机构
[1] GLAXO WELLCOME RES,DIV MED CHEM,RES TRIANGLE PK,NC 27709
关键词
D O I
10.1016/0040-4039(96)00385-1
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Di- and tripeptide aldehydes were found to undergo reaction with methanol to afford the corresponding methyl hemiacetals. These compounds, which possessed unusual stability, were isolated and characterized using NMR techniques and a chemical correlation experiment. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码:2521 / 2524
页数:4
相关论文
共 6 条
[1]   SYNTHESIS OF CHIRAL PIPERAZIN-2-ONES AS MODEL PEPTIDOMIMETICS [J].
DIMAIO, J ;
BELLEAU, B .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1989, (09) :1687-1689
[2]   LAURALDEHYDE - HEMIACETAL FORMATION [J].
ERICKSON, JLE ;
CAMPBELL, CR .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1954, 76 (17) :4472-4473
[3]   HEMIACETALS ALDALS AND HEMIALDALS [J].
HURD, CD .
JOURNAL OF CHEMICAL EDUCATION, 1966, 43 (10) :527-&
[4]  
MARCH J, 1985, ADV ORG CHEM, P790
[5]   N-METHOXY-N-METHYLAMIDES AS EFFECTIVE ACYLATING AGENTS [J].
NAHM, S ;
WEINREB, SM .
TETRAHEDRON LETTERS, 1981, 22 (39) :3815-3818
[6]  
SPALTENSTEIN A, 1996, TETRAHEDRON LETT, V37