SEARCH FOR GENOMIC SEQUENCES OF MICROBIAL AGENTS IN ATHEROSCLEROTIC PLAQUES

被引：10

作者：

Tremolada, S.

Delbue, S. ^{[2
]}

Ferraresso, M. ^{[3
]}

Carloni, C.

Elia, F. ^{[2
]}

Larocca, S.

Bortolani, E. ^{[3
]}

Ferrante, P. ^{[1
,2
]}

机构：

[1] Univ Milan, Lab Translat Res, Dept Publ Hlth Microbiol Virol, I-20133 Milan, Italy

[2] Hlth Sci Fdn, Fdn Ettore Sansavini Ric Sci, Lugo, Ravenna, Spain

[3] Univ Milan, Div Gen & Vasc Surg, Dept Surg Sci, St Joseph Hosp, Milan, Italy

来源：

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY | 2011年 / 24卷 / 01期

关键词：

atherosclerosis; injection; human herpesvirus; Chlamydia pneumoniae; EPSTEIN-BARR-VIRUS; MULTIPLE-SCLEROSIS; INFECTIOUS AGENTS; CYTOMEGALOVIRUS; PNEUMONIAE; DNA; DISEASE; MEN;

D O I：

10.1177/039463201102400130

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Atherosclerosis is a complex, multifactorial disease. Several studies have reported a possible association between infection with microbial agents and atherogenesis. Chlamydia pneumoniae (C. pneumoniae), Herpes Simplex Virus 1 (HSV1), Human Cytomegalovirus (HCMV), and Epstein Barr Virus (EBV) have been widely investigated for their possible role in atherosclerosis development, but the results obtained to date are contradictory. The aim of our study is to search DNA of the aforementioned infectious agents by means of Quantitative Real Time PCR in atherosclerotic plaques from carotid arteries obtained from 17 patients. Genomic sequences of C. pneumoniae, HSV1, HCMV were not found in any atherosclerotic lesion. Therefore, our results do not support the hypothesis of an association between these infectious agents and atherosclerosis. Conversely, three patients were found to be positive for EBV DNA, thus indicating that, at least in a limited number of patients, EBV could play a role in atherogenesis.

引用

页码：243 / 246

页数：4

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