Expression of the human germinal-centre-associated lymphoma protein in diffuse large B-cell lymphomas in patients with rheumatoid arthritis

被引：18

作者：

Baecklund, Eva ^{[1
]}

Natkunam, Yasodha ^{[2
]}

Backlin, Carin ^{[3
]}

Iliadou, Anastasia ^{[4
]}

Askling, Johan ^{[5
,6
]}

Ekbom, Anders ^{[5
]}

Feltelius, Nils ^{[7
]}

Klareskog, Lars ^{[6
]}

Enblad, Gunilla ^{[8
]}

Lossos, Izidore S. ^{[9
]}

Levy, Ronald ^{[10
]}

Sundstroem, Christer ^{[3
]}

Rosenquist, Richard ^{[3
]}

机构：

[1] Univ Uppsala Hosp, Dept Rheumatol, SE-75185 Uppsala, Sweden

[2] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA

[3] Uppsala Univ, Dept Genet & Pathol, Uppsala, Sweden

[4] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[5] Karolinska Univ Hosp, Clin Epidemiol Unit, Dept Med, Karolinska Inst, Stockholm, Sweden

[6] Karolinska Univ Hosp, Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden

[7] Swedish Med Prod Agcy, Uppsala, Sweden

[8] Uppsala Univ, Dept Oncol Radiol & Clin Immunol, Uppsala, Sweden

[9] Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL 33152 USA

[10] Stanford Univ, Med Ctr, Dept Med, Div Oncol, Stanford, CA 94305 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2008年 / 141卷 / 01期

关键词：

human germinal-centre-associated protein; lymphoma; rheumatoid arthritis; diffuse large B-cell lymphoma; B-cells;

D O I：

10.1111/j.1365-2141.2008.07011.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diffuse large B-cell lymphomas (DLBCL) can be subdivided into germinal centre (GC)-like and non-GC-like subtypes by CD10, BCL6 and MUM1/IRF4 status. We previously reported that patients with severe rheumatoid arthritis (RA) are at increased risk of non-GC DLBCL. This study examined a new GC-marker, human germinal-centre-associated lymphoma (HGAL) protein, in RA-DLBCL. Of 111, 38 (34%) DLBCL were HGAL-positive and showed less disseminated disease and a tendency toward improved overall survival compared to HGAL-negative cases. This supports that a majority of RA-DLBCL are of non-GC origin, indicating a specific role for activated peripheral B cells in the pathogenesis of RA-DLBCL.

引用

页码：69 / 72

页数：4

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