Novel α-glucosidase inhibitors from Macaranga tanarius leaves

被引：73

作者：

Gunawan-Puteri, Maria D. P. T. ^{[1
]}

Kawabata, Jun ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Agr, Div Appl Biosci, Kita Ku, Sapporo, Hokkaido 0608589, Japan

来源：

FOOD CHEMISTRY | 2010年 / 123卷 / 02期

关键词：

Indonesian herb; Macaranga tanarius; Ellagitannin; alpha-Glucosidase inhibitor; Diabetes; Macatannin; HYDROLYZABLE TANNINS; ELLAGITANNINS; ACARBOSE; DISEASE; VIRUS;

D O I：

10.1016/j.foodchem.2010.04.050

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

One of the hyperglycaemic remedies is glucose absorption reduction by suppressing carbohydrate digestion due to utilisation of alpha-glucosidase inhibitors (AGIs). Determination of prospecting herbs done in vitro by using enzyme assay resulted in the finding of Macaranga tanarius, which showed a potent inhibitory activity. An EtOAc-soluble extract of M. tanarius leaves was chromatographed by a Diaion HP-20 column and the active fractions were further purified with high performance liquid chromatography (HPLC) to isolate active principles against alpha-glucosidase. Five ellagitannins were successfully isolated and identified. Structure determination revealed that these isolated compounds were mallotinic acid (IC50 > 5.00 mM), corilagin (IC50 = 2.63 mM), chebulagic acid (IC50 = 1.00 mM), and two novel compounds named macatannins A (IC50 = 0.80 mM) and B (IC50 = 0.55 mM). AGIs play an important role for the treatment of diabetes, therefore this research results may suggest novel alternatives for diabetes treatment management. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：384 / 389

页数：6

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