A benzothiophene-carboxamide is a potent inhibitor of IL-1 beta induced VCAM-1 gene expression in human endothelial cells

被引：22

作者：

Cobb, RR

Felts, KA

McKenzie, TC

Parry, GCN

Mackman, N

机构：

[1] DEPT CHEM, TANABE RES LABS, SAN DIEGO, CA 92121 USA

[2] Scripps Res Inst, DEPT IMMUNOL, LA JOLLA, CA 92037 USA

[3] Scripps Res Inst, DEPT VASC BIOL, LA JOLLA, CA 92037 USA

来源：

FEBS LETTERS | 1996年 / 382卷 / 03期

关键词：

VCAM-1; inhibition; transcription; nuclear factor kappa B; benzothiophene-carboxamide;

D O I：

10.1016/0014-5793(96)00202-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vascular endothelial cells respond to cytokines such as IL-1 beta or TNF-alpha by undergoing a number of functional alterations. Among these alterations is the induction of cell surface adhesion molecules, including VCAM-1. In this report, ,ve investigated the effects of a 3-alkoxybenzo[beta]thiophene-2-carboxamide (BZT) on the cytokine induction of VCAM-1 expression and activation of the transcription factor NF-kappa B in human endothelial cells. BZT blocked the IL-1 beta induced cell surface expression of VCAM-1 in human endothelial cells but did not prevent nuclear translocation of NF-kappa B. This study demonstrates that BZT is a potent inhibitor of VCAM-1 expression in human endothelial cells.

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页码：323 / 326

页数：4

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