Deregulated over expression of FOXP1 protein in diffuse large B-cell lymphoma does not occur as a result of gene rearrangement

被引：10

作者：

Barrans, Sharon L. ^{[1
]}

Fenton, James A. L. ^{[1
]}

Ventura, Roland ^{[2
]}

Smith, Alex ^{[3
]}

Banham, Alison H. ^{[2
]}

Jack, Andrew S. ^{[1
]}

机构：

[1] Leeds Gen Infirm, Acad Unit Haematol & Oncol, HMDS, Leeds LS1 3EX, W Yorkshire, England

[2] Univ Oxford, Nuffield Dept Clin Lab Sci, LRF Lymphoma Antigens Programme, John Radcliffe Hosp, Oxford, England

[3] Univ York, Epidemiol & Genet Unit, York, N Yorkshire, England

来源：

HAEMATOLOGICA | 2007年 / 92卷 / 06期

关键词：

D O I：

10.3324/haematol.10656

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Strong uniform expression of FOXP1 protein occurs in a subgroup of non-germinal centre (GC) diffuse large B-cell lymphomas (DLBCL). We have investigated gene rearrangement as a potential mechanism for deregulated expression of FOXP1 however, using FISH FOXP1 translocations were not found in any case with over-expression of the protein.

引用

页码：863 / 864

页数：2

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